What Does Pyrogen-Free Mean? Understanding Apyrogenicity

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The term 'pyrogen-free' or 'apyrogenic' refers to the absence of pyrogens in a substance or product. Pyrogens are fever-inducing substances, often bacterial endotoxins, that can cause adverse reactions when introduced into the body. In medical and pharmaceutical contexts, ensuring products are pyrogen-free is crucial to patient safety. This involves rigorous testing and sterilization processes to eliminate or neutralize any pyrogens that may be present. Products labeled as 'pyrogen-free' have undergone these processes and meet specific regulatory standards.

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